解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The authors utilized two groups of adult male rats to study the effect of chronic-uremic toxemia on the synthesis of thyroid hormones. The control group was sham operated, while the other group had about 70--80% of the left kidney tissue surgically excised and a total right nephrectomy performed 10 days later. At the ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181516
更新日期:1978-01-01 00:00:00
abstract::In 25 patients with nephrotic syndromes of different origin, indomethacin caused an immediate decrease in glomerular filtration rate (GFR) and urinary protein excretion. This effect of indomethacin on GFR and proteinuria was more pronounced when the renin-angiotensin system was stimulated by a low-sodium diet and 50 m...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181478
更新日期:1978-01-01 00:00:00
abstract::The kinetics of bromosulfophthalein clearance from plasma, secretion into bile, and, by difference, storage in hepatic cells, were determined, using normal livers and blood from normal rats in the isolated perfused rat liver system. Two suspected uremic 'toxins', urea and guanidinosuccinic acid, were then administered...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181467
更新日期:1978-01-01 00:00:00
abstract::15 patients who had benign, uncomplicated essential hypertension, were treated with chlorthiazide (500 mg twice a day) with or without propranolol (10--20 mg 4 times a day), and the effect of the treatment on plasma renin activity (PRA), urinary aldosterone excretion, total body potassium (TBK) and plasma sodium and p...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000181403
更新日期:1978-01-01 00:00:00
abstract::Clearance techniques were used to evaluate renal tubular sodium and water excretion in 4 patients with antibiotic-induced acute renal failure (ARF). Creatinine clearances and maximal urine flow rates of patients with ARF (22.6 and 5.23 ml/min, respectively) were significantly lower than control values during hypotonic...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181226
更新日期:1978-01-01 00:00:00
abstract::A modified sieving technique has been developed to isolate pure glomeruli from monkey, sheep, dog, rabbit and rat kidney. Glomeruli from all these species have been grown in tissue culture and the glomerular cell outgrowth studied by light microscopy and time-lapse cinemicroscopy. The pattern of growth was the same fo...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181513
更新日期:1978-01-01 00:00:00
abstract::The morphologic basis of proteinuria in experimental chronic serum sickness glomerulonephritis in rabbits was studied by light and electron microscopy using horseradish peroxidase (effective radius 30 A; mol. wt. 40,000) and ferritin (effective radius 60 A; mol. wt. 480,000) as protein tracers. It was found that more ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181260
更新日期:1978-01-01 00:00:00
abstract::Serial changes in plasma of renin concentration (PRC), renin-substrate concentration (PSC) and renin activity (PRA) were followed in rats during glycerol-induced acute renal failure. There was an early but transient increase in PRC and a more delayed and prolonged rise in PSC. PRA began to rise a few hours after glyce...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181196
更新日期:1978-01-01 00:00:00
abstract::A 62-year-old white male suffering from plasmacytosis with monoclonal gammopathy developed gastrointestinal bleeding, microscopic hematuria, proteinuria and progressive azotemia. A renal biopsy demonstrated capillary wall thickening, mesangial hyperplasia, crescent formation and subepithelial humps. Serum immunoglobul...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180902
更新日期:1977-01-01 00:00:00
abstract::Plasma renin reactivity (PRR) is the in vitro rate of angiotensin generation after addition of exogenous renin to plasma. The purpose of the present study is to compare measurements of PRR in venous effluent from the involved and uninvolved kidneys in both experimental and clinical renovascular hypertension. A two-kid...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180893
更新日期:1977-01-01 00:00:00
abstract::Micropuncture studies were performed in intact and thyroparathyroidectomized (TPTX) dogs to evaluate the relationship between the absolute level of serum ultrafilterable phosphate concentration (SUFP) and proximal bicarbonate reabsorption. In both groups of animals, a reverse linear relationship was noted between the ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180864
更新日期:1977-01-01 00:00:00
abstract::The renal cortex of anesthetized dogs was found to contain per gram lyophilized dry weight 9.5+/-0.6 micronmol ATP, 3.2+/-0.5 MICRONMOL ADP, 0.68+/-0.3 MICRONMOL AMP, and 22.5+/-4.4 micronmol Pi. These amounts were unchanged by the administration of moderate amounts of saline or hypertonic mannitol in load doses of ab...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180833
更新日期:1977-01-01 00:00:00
abstract::Familial lecithin-cholesterol acyltransferase deficiency is a hereditary disorder of lipid metabolism. Lipid material is deposited in the kidneys, the glomerular capillary basement membrane is irregularly thickened, detachment and even loss of endothelial cells are seen in the glomeruli. Proteinuria was present in 8 o...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180835
更新日期:1977-01-01 00:00:00
abstract::The effect of changes in the dialysate calcium concentration on calcium fractions and parathyroid hormone species in plasma during hemodialysis has been examined. C-terminal immunoreactive parathyroid hormone was suppressed when plasma calcium increased by greater than 25% whereas N-terminal fragments demonstrated an ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180870
更新日期:1977-01-01 00:00:00
abstract::An unusual case of progressive systemic sclerosis with rapidly progressing renal failure after a successful delivery is described. The presenting syndrome was malignant hypertension. The blood pressure was refractory to the various therapeutic measures which were instituted, including hemodialysis. The patient, theref...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180812
更新日期:1977-01-01 00:00:00
abstract::Exaggerated natriuresis in response to hypertonic saline infusion occurs with great regularity in patients with documented previous attacks of poststreptococcal glomerulonephritis. Five patients were studied before and after 1 week of dietary sodium restriction in order to examine the possibility that increased extrac...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180852
更新日期:1977-01-01 00:00:00
abstract::During the 12 weeks following 5/6 nephrectomy in rats with moderate uremia (creatinine 0.7-1.2 mg/100 ml, BUN 53-89 mg/100 ml), no significant increases in total soft tissue calcification were observed. The calcium concentration of skeletal muscle remained unchanged at 4, 8, and 12 weeks after surgery. A slight but no...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180786
更新日期:1977-01-01 00:00:00
abstract::A new case of acute renal failure after rifampicin is presented, together with a review of the 36 similar cases published up to date in the literature. Evidence is provided that irregularities in drug intake, either as true intermittent treatment or as discontinuation of continuous therapy, play an important role in t...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000180596
更新日期:1976-01-01 00:00:00
abstract::Mixed IgM-IgG cryoglobulins were present in the serum of a patient with the nephrotic syndrome, recurrent purpura, chronic active hepatitis and ascites. A renal biopsy demonstrated deposition of IgM, IgG, and complement components C3 and C4 in intracapillary 'coagula' and glomerular capillary walls. No glomerular depo...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180591
更新日期:1976-01-01 00:00:00
abstract::In Wistar rats V-U reflux with distilled water and sterile saline of varying osmolar strength produces scars in the perihilar region of the kidneys in 80% of animals. Using Indian ink as a marker, rupture of the forniceal epithelium regularly followed V-U reflux. Intrapelvic pressure rose to 120 mm Hg during the reflu...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180706
更新日期:1976-01-01 00:00:00
abstract::In 42 untreated patients at various stages of chronic renal failure, plasma level of parathyroid hormone was directly proportional to the degree of renal failure and inversely proportional to the serum calcium level. Plasma parathyroid hormone levels were frequently elevated in 21 patients undergoing regular dialysis ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180720
更新日期:1976-01-01 00:00:00
abstract::The renal biopsies of 15 patients affected by polydipsia syndromes were examined under light and electron microscopes. The authors contend that the observed renal lesions (dilatation of the glomerular loops, tubular hypertrophy and vacuolization, and basal membrane swelling) are the morphologic result of tubular hyper...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180606
更新日期:1976-01-01 00:00:00
abstract::A preparation for performance of renal clearances in the conscious dog is described. The important aspect of the technique is the use of a Pavlov sling and a specially designed restraining apparatus. Of most importance is the use of a 7 French Swan-Ganz balloon-tipped catheter for urinary bladder catheterization. The ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180595
更新日期:1976-01-01 00:00:00
abstract::Pericardial drainage via percutaneous catheter placement and local nonabsorbable steroid instillation was employed as definitive therapy for uremic patients who had intractable pericardial effusions. Twelve patients are reported. Prior daily dialysis, and in one case systemic steroids, were not curative. 11 of 12 case...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180622
更新日期:1976-01-01 00:00:00
abstract::Glycoprotein: galactosyl and glycoprotein: sialic acid transferase activities were measured in the serum of patients with minimal lesion nephrotic syndrome, acute renal failure, and chronic renal insufficiency of varying severity. The activity of galactosyl transferase was elevated in all patients but one. Sialic acid...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000180711
更新日期:1976-01-01 00:00:00
abstract::The effects of intravenous iron, with and without androgens, was studied in a group of 39 patients treated by regular haemodialysis, almost all of whom had normal serum iron concentrations. Intravenous iron 1-2 g every 4 months produced a significant rise in haemoglobin from 6.3 to 7.9 g/dl in 17 female patients with ...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000180751
更新日期:1976-01-01 00:00:00
abstract::A reduction in the serum urate concentration in hyperuricemic subjects can be achieved by increasing the renal excretion of uric acid, by inhibiting its synthesis, or by a combination of both modalities. The three most commonly used hypouricemic drugs are probenecid, sulfinpyrazone and allopurinol. Each drug has been ...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000180439
更新日期:1975-01-01 00:00:00
abstract::The effect of the length of hemodialysis on the outcome of renal transplant was evaluated in 43 recipients of renal allograft. 22 out of 23 patients (95.7%) dialyzed for longer than one year had an excellent renal function at one year, while only 10 out of 20 patients (50%) dialyzed for less than one year had good ren...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180475
更新日期:1975-01-01 00:00:00
abstract::Survival after serum creatinine exceeded 10.0 mg/100 ml was increased if one peritoneal dialysis was performed. After one peritoneal dialysis 'survival' of 62 patients to the present time, death or the next dialysis averaged 119 days; median survival was 28 days. Characteristics of prolonged survivors were persisten...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180488
更新日期:1975-01-01 00:00:00
abstract::We recently showed in dogs that there is a close relationship between bicarbonate reabsorption and glomerular filtration rate (GFR). The present studies were designed to confirm these findings in five normal men. Bicarbonate titrations were done after ingesting a low protein diet for one week and were repeated followi...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180453
更新日期:1975-01-01 00:00:00
abstract::Renal nerves were stimulated either directly (loop electrodes) or indirectly (bilateral carotid occlusion with maintenance of control blood pressure) in anesthetized dogs to determine the effects on renal blood flow (RBF), glomerular filtration rate (GFR), sodium excretion (UNaV), and intrarenal distribution of blood ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180454
更新日期:1975-01-01 00:00:00
abstract::A 62-year-old woman gave clinical manifestation of liver cirrhosis. Urinary protein was false positive, no uremia was found and renal changes were entirely overlooked. Deposition of abundant lipids (globoside and ceramide trihexoside) was found in the kidneys; essentially degenerative changes of the tubular epithelia ...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000180480
更新日期:1975-01-01 00:00:00
abstract::Three unusual cases are described which demonstrated hypomagnesemia and symptoms resembling magnesium deficiency syndrome. The hypomagnesemia was most likely secondary to urinary losses from diuresis following release of post-renal obstruction and renal homotransplantation. Heretofore, this association has not been de...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180457
更新日期:1975-01-01 00:00:00
abstract::Calcitonin, whatever its origin, produces a decrease in the renal tubular reabsorption of sodium, phosphate and calcium in man and in the rat. Renal receptors for calcitonin have been demonstrated in the membranes of rat tubular cells using 125I salmon calcitonin as a tracer. Hormone-receptor interaction initiates the...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000180515
更新日期:1975-01-01 00:00:00
abstract::Changes in renal function and structure are frequently observed in patients with diabetes mellitus. In the early phases of the disease, alterations in glomerular filtration rate, renal plasma flow, glomerular permeability and tubular capacity for glucose reabsorption occur. In the late stages of juvenile onset diabete...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000180518
更新日期:1975-01-01 00:00:00